Complement Component C3 Participates in Early Stages of Niemann–Pick C Mouse Liver Damage

Niemann–Pick type C (NPC), a lysosomal storage disorder, is mainly caused by mutations in the NPC1 gene. Niemann–Pick type C patients and mice show intracellular cholesterol accumulation leading to hepatic failure with increased inflammatory response. The complement cascade, which belongs to the inn...

Descripción completa

Detalles Bibliográficos
Autores principales: Klein, Andrés D., González de la Vega, Javier, Zanlungo, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139721/
https://www.ncbi.nlm.nih.gov/pubmed/32244854
http://dx.doi.org/10.3390/ijms21062127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139721/
https://www.ncbi.nlm.nih.gov/pubmed/32244854
http://dx.doi.org/10.3390/ijms21062127

Ejemplares similares