Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA

Deregulation of pre-mRNA splicing is observed in many cancers and hematological malignancies. Genes encoding splicing factors are frequently mutated in myelodysplastic syndromes, in which SF3B1 mutations are the most frequent. SF3B1 is an essential component of the U2 small nuclear ribonucleoprotein...

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Detalles Bibliográficos
Autores principales: Bergot, Tiffany, Lippert, Eric, Douet-Guilbert, Nathalie, Commet, Séverine, Corcos, Laurent, Bernard, Delphine G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139785/
https://www.ncbi.nlm.nih.gov/pubmed/32168916
http://dx.doi.org/10.3390/cancers12030652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139785/
https://www.ncbi.nlm.nih.gov/pubmed/32168916
http://dx.doi.org/10.3390/cancers12030652

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