Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine

7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can be considered as a potential anticancer drug candidate. Here we describe a study of 7-MG inhibition mechanism using molecular dynamics, fluorescence anisotropy and single-particle F...

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Detalles Bibliográficos
Autores principales: Nilov, Dmitry, Maluchenko, Natalya, Kurgina, Tatyana, Pushkarev, Sergey, Lys, Alexandra, Kutuzov, Mikhail, Gerasimova, Nadezhda, Feofanov, Alexey, Švedas, Vytas, Lavrik, Olga, Studitsky, Vasily M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139824/
https://www.ncbi.nlm.nih.gov/pubmed/32245127
http://dx.doi.org/10.3390/ijms21062159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139824/
https://www.ncbi.nlm.nih.gov/pubmed/32245127
http://dx.doi.org/10.3390/ijms21062159

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