PDI-Mediated Reduction of Disulfide Bond on PSD95 Increases Spontaneous Seizure Activity by Regulating NR2A–PSD95 Interaction in Epileptic Rats Independent of S-Nitrosylation

Postsynaptic density-95 (PSD95), a major scaffolding protein, is critical in coupling N-methyl-D-aspartate receptor (NMDAR) to cellular signaling networks in the central nervous system. A couple of cysteine residues in the N-terminus of PSD95 are potential sites for disulfide bonding, S-nitrosylatio...

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Detalles Bibliográficos
Autores principales: Lee, Duk-Shin, Kim, Ji-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139850/
https://www.ncbi.nlm.nih.gov/pubmed/32197489
http://dx.doi.org/10.3390/ijms21062094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139850/
https://www.ncbi.nlm.nih.gov/pubmed/32197489
http://dx.doi.org/10.3390/ijms21062094

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