Tuning the Polymorphism of the Anti-VEGF G-rich V7t1 Aptamer by Covalent Dimeric Constructs

In the optimization process of nucleic acid aptamers, increased affinity and/or activity are generally searched by exploring structural analogues of the lead compound. In many cases, promising results have been obtained by dimerization of the starting aptamer. Here we studied a focused set of covale...

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Detalles Bibliográficos
Autores principales: Riccardi, Claudia, Musumeci, Domenica, Platella, Chiara, Gaglione, Rosa, Arciello, Angela, Montesarchio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139925/
https://www.ncbi.nlm.nih.gov/pubmed/32183039
http://dx.doi.org/10.3390/ijms21061963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139925/
https://www.ncbi.nlm.nih.gov/pubmed/32183039
http://dx.doi.org/10.3390/ijms21061963

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