Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer

In colorectal cancer (CRC), upregulation of the C-X-C motif chemokine receptor 4 (CXCR4) is correlated with metastasis and poor prognosis, highlighting the need to further elucidate CXCR4’s regulation in CRC. For the first time, DNA methylation and 5-hydroxymethylcytosine aberrations were investigat...

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Detalles Bibliográficos
Autores principales: Stuckel, Alexei J., Zhang, Wei, Zhang, Xu, Zeng, Shuai, Dougherty, Urszula, Mustafi, Reba, Zhang, Qiong, Perreand, Elsa, Khare, Tripti, Joshi, Trupti, West-Szymanski, Diana C., Bissonnette, Marc, Khare, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139960/
https://www.ncbi.nlm.nih.gov/pubmed/32110952
http://dx.doi.org/10.3390/cancers12030539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139960/
https://www.ncbi.nlm.nih.gov/pubmed/32110952
http://dx.doi.org/10.3390/cancers12030539

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