MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells

MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While TP53 deletion is rare in glioblastomas, these tumors often carry TP53 mutations. Here, we show that MK2 inhibition strongly attenuated gliob...

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Detalles Bibliográficos
Autores principales: Phoa, Athena F., Recasens, Ariadna, Gurgis, Fadi M. S., Betts, Tara A., Menezes, Sharleen V., Chau, Diep, Nordfors, Kristiina, Haapasalo, Joonas, Haapasalo, Hannu, Johns, Terrance G., Stringer, Brett W., Day, Bryan W., Buckland, Michael E., Lalaoui, Najoua, Munoz, Lenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139970/
https://www.ncbi.nlm.nih.gov/pubmed/32168910
http://dx.doi.org/10.3390/cancers12030654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139970/
https://www.ncbi.nlm.nih.gov/pubmed/32168910
http://dx.doi.org/10.3390/cancers12030654

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