Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors

Atypical teratoid rhabdoid tumors (ATRTs) are among the most malignant brain tumors in early childhood and remain incurable. Myc-ATRT is driven by the Myc oncogene, which directly controls the intracellular protein synthesis rate. Proteasome inhibitor bortezomib (BTZ) was approved by the Food and Dr...

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Detalles Bibliográficos
Autores principales: Tran, Huy Minh, Wu, Kuo-Sheng, Sung, Shian-Ying, Changou, Chun Austin, Hsieh, Tsung-Han, Liu, Yun-Ru, Liu, Yen-Lin, Tsai, Min-Lan, Lee, Hsin-Lun, Hsieh, Kevin Li-Chun, Huang, Wen-Chang, Liang, Muh-Lii, Chen, Hsin-Hung, Lee, Yi-Yen, Lin, Shih-Chieh, Ho, Donald Ming-Tak, Chang, Feng-Chi, Chao, Meng-En, Chen, Wan, Chu, Shing-Shung, Yu, Alice L., Yen, Yun, Chang, Che-Chang, Wong, Tai-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140067/
https://www.ncbi.nlm.nih.gov/pubmed/32235770
http://dx.doi.org/10.3390/cancers12030752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140067/
https://www.ncbi.nlm.nih.gov/pubmed/32235770
http://dx.doi.org/10.3390/cancers12030752

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