Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation

Glucocorticoid (GC) resistance is a crucial determinant of inferior response to chemotherapy in pediatric acute lymphoblastic leukemia (ALL); however, molecular mechanisms underlying this phenomenon are poorly understood. Deregulated splicing is a common feature of many cancers, which impacts drug r...

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Detalles Bibliográficos
Autores principales: Sciarrillo, Rocco, Wojtuszkiewicz, Anna, Kooi, Irsan E., Leon, Leticia G., Sonneveld, Edwin, Kuiper, Roland P., Jansen, Gerrit, Giovannetti, Elisa, Kaspers, Gertjan J.L., Cloos, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140081/
https://www.ncbi.nlm.nih.gov/pubmed/32204435
http://dx.doi.org/10.3390/cancers12030723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140081/
https://www.ncbi.nlm.nih.gov/pubmed/32204435
http://dx.doi.org/10.3390/cancers12030723

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