Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype defined by lack of hormone receptor expression and non-amplified HER2. Adavosertib (AZD1775) is a potent, small-molecule, ATP-competitive inhibitor of the Wee1 kinase that potentiates the activity of many DNA-damaging chemotherapeutics an...

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Detalles Bibliográficos
Autores principales: Pitts, Todd M., Simmons, Dennis M., Bagby, Stacey M., Hartman, Sarah J., Yacob, Betelehem W., Gittleman, Brian, Tentler, John J., Cittelly, Diana, Ormond, D. Ryan, Messersmith, Wells A., Eckhardt, S. Gail, Diamond, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140086/
https://www.ncbi.nlm.nih.gov/pubmed/32204315
http://dx.doi.org/10.3390/cancers12030719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140086/
https://www.ncbi.nlm.nih.gov/pubmed/32204315
http://dx.doi.org/10.3390/cancers12030719

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