Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy

Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that plant ROP and yeast Cdc42 GTPases similarly modulate Ser2 and Ser5 phosphorylation status of the C-terminal domain (CTD) of the...

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Zhong, Xuelin, Sauane, Moira, Zhao, Yihong, Zheng, Zhi-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140432/
https://www.ncbi.nlm.nih.gov/pubmed/32143485
http://dx.doi.org/10.3390/cells9030621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140432/
https://www.ncbi.nlm.nih.gov/pubmed/32143485
http://dx.doi.org/10.3390/cells9030621

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