Cargando…

Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy

Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that plant ROP and yeast Cdc42 GTPases similarly modulate Ser2 and Ser5 phosphorylation status of the C-terminal domain (CTD) of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Bo, Zhong, Xuelin, Sauane, Moira, Zhao, Yihong, Zheng, Zhi-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140432/ https://www.ncbi.nlm.nih.gov/pubmed/32143485 http://dx.doi.org/10.3390/cells9030621

Ejemplares similares

Gene-specific RNA pol II phosphorylation and the "CTD code"
por: Kim, Hyunmin, et al.
Publicado: (2010)

Stimulation of Fascin Spikes by Thrombospondin-1 Is Mediated by the Gtpases Rac and Cdc42
por: Adams, Josephine Clare, et al.
Publicado: (2000)

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
por: Blattner, Simone M., et al.
Publicado: (2013)

Targeting Rac and Cdc42 GEFs in Metastatic Cancer
por: Maldonado, Maria del Mar, et al.
Publicado: (2020)

Evidence for a Novel Mechanism of the PAK1 Interaction with the Rho-GTPases Cdc42 and Rac
por: Shin, Yong Jae, et al.
Publicado: (2013)

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases
por: Oprea, Tudor I., et al.
Publicado: (2015)

Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport
por: Kolyvushko, Oleksandr, et al.
Publicado: (2020)

Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC1/Cdc42 Small GTPase phosphorylation and activation
por: Zeng, Canjun, et al.
Publicado: (2016)

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD
por: Koga, Mitsunori, et al.
Publicado: (2015)

The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
por: Liu, Yuan, et al.
Publicado: (2020)

Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells
por: Hoshino, Mitsunobu, et al.
Publicado: (2003)

Synthetic Lethality Targeting Polθ
por: Drzewiecka, Małgorzata, et al.
Publicado: (2022)

Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics
por: Man Tsang, Siu, et al.
Publicado: (2012)

The evolutionary history of effectors downstream of Cdc42 and Rac
por: Cotteret, Sophie, et al.
Publicado: (2002)

Mediator and Pol II go to eleven (CTD repeats)
por: Kaplan, Craig D.
Publicado: (2023)

Optogenetic dissection of Rac1 and Cdc42 gradient shaping
por: de Beco, S., et al.
Publicado: (2018)

Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models
por: Torres-Sanchez, Anamaris, et al.
Publicado: (2023)

CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis
por: Caron, Christine, et al.
Publicado: (2016)

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins
por: Schlam, Daniel, et al.
Publicado: (2015)

A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice
por: Zins, Karin, et al.
Publicado: (2013)

Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells
por: Gao, Lei, et al.
Publicado: (2013)

Functional Characterization and Cellular Dynamics of the CDC-42 – RAC – CDC-24 Module in Neurospora crassa
por: Araujo-Palomares, Cynthia L., et al.
Publicado: (2011)

Distinct predictive performance of Rac1 and Cdc42 in cell migration
por: Yamao, Masataka, et al.
Publicado: (2015)

Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1
por: Han, Zhong, et al.
Publicado: (2020)

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
por: Brindani, Nicoletta, et al.
Publicado: (2023)

Rac1 GTPase in pancreatic cancer
por: Yan, Ying, et al.
Publicado: (2015)

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis
por: Duan, Xin, et al.
Publicado: (2021)

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes
por: Cox, Dianne, et al.
Publicado: (1997)

Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis
por: Das, Maitreyi, et al.
Publicado: (2015)

Imaging Dynamic Molecular Signaling by the Cdc42 GTPase within the Developing CNS
por: Sharifai, Nima, et al.
Publicado: (2014)

Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion
por: Sartorel, Elodie, et al.
Publicado: (2018)

Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling
por: Lu, Michelle Seiko, et al.
Publicado: (2020)

The Small GTPase Cdc42 Is a Major Regulator of Neutrophil Effector Functions
por: Tackenberg, Heidi, et al.
Publicado: (2020)

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
por: Kalim, Khalid W, et al.
Publicado: (2022)

Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
por: Wirth, Alexander, et al.
Publicado: (2023)

The Fission Yeast Stress-Responsive MAPK Pathway Promotes Meiosis via the Phosphorylation of Pol II CTD in Response to Environmental and Feedback Cues
por: Sukegawa, Yuko, et al.
Publicado: (2011)

A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation
por: Dronamraju, Raghuvar, et al.
Publicado: (2014)

Role of Activated Rac1/Cdc42 in Mediating Endothelial Cell Proliferation and Tumor Angiogenesis in Breast Cancer
por: Ma, Ji, et al.
Publicado: (2013)

The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42
por: Zhu, Zhonglin, et al.
Publicado: (2019)

Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_42tuh9ict5faiaf78rhlbg4gun