The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias

The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and in...

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Detalles Bibliográficos
Autores principales: Pippa, Raffaella, Odero, Maria D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140463/
https://www.ncbi.nlm.nih.gov/pubmed/32110991
http://dx.doi.org/10.3390/cells9030544
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author Pippa, Raffaella
Odero, Maria D.
author_facet Pippa, Raffaella
Odero, Maria D.
author_sort Pippa, Raffaella
collection PubMed
description The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other’s activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.
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spelling pubmed-71404632020-04-13 The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias Pippa, Raffaella Odero, Maria D. Cells Review The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other’s activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias. MDPI 2020-02-26 /pmc/articles/PMC7140463/ /pubmed/32110991 http://dx.doi.org/10.3390/cells9030544 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pippa, Raffaella
Odero, Maria D.
The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
title The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
title_full The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
title_fullStr The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
title_full_unstemmed The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
title_short The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
title_sort role of myc and pp2a in the initiation and progression of myeloid leukemias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140463/
https://www.ncbi.nlm.nih.gov/pubmed/32110991
http://dx.doi.org/10.3390/cells9030544
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