Predicting liver cytosol stability of small molecules

Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of cytosolic enzymes until much later in the drug...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Pranav, Siramshetty, Vishal B., Zakharov, Alexey V., Southall, Noel T., Xu, Xin, Nguyen, Dac-Trung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140498/
https://www.ncbi.nlm.nih.gov/pubmed/33431020
http://dx.doi.org/10.1186/s13321-020-00426-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140498/
https://www.ncbi.nlm.nih.gov/pubmed/33431020
http://dx.doi.org/10.1186/s13321-020-00426-7

Ejemplares similares