At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer

BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins...

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Detalles Bibliográficos
Autores principales: Kögel, Donat, Linder, Benedikt, Brunschweiger, Andreas, Chines, Silvia, Behl, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140512/
https://www.ncbi.nlm.nih.gov/pubmed/32121220
http://dx.doi.org/10.3390/cells9030574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140512/
https://www.ncbi.nlm.nih.gov/pubmed/32121220
http://dx.doi.org/10.3390/cells9030574

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