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Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC
Inhibitors of apoptosis (IAPs) are a family of proteins that regulate cell death and inflammation. XIAP (X-linked IAP) is the only family member that suppresses apoptosis by directly binding to and inhibiting caspases. On the other hand, cIAPs suppress the activation of the extrinsic apoptotic pathw...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140716/ https://www.ncbi.nlm.nih.gov/pubmed/32182843 http://dx.doi.org/10.3390/cells9030663 |