Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R–mediated STAT3 activation

Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern, whose effect on macrophages is not entirely elucidated. Here we identified that eCIRP promotes macrophage endotoxin tolerance. Septic mice had higher serum levels of eCIRP; this was associated with a r...

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Detalles Bibliográficos
Autores principales: Zhou, Mian, Aziz, Monowar, Denning, Naomi-Liza, Yen, Hao-Ting, Ma, Gaifeng, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141386/
https://www.ncbi.nlm.nih.gov/pubmed/32027619
http://dx.doi.org/10.1172/jci.insight.133715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141386/
https://www.ncbi.nlm.nih.gov/pubmed/32027619
http://dx.doi.org/10.1172/jci.insight.133715

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