Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice

Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRN...

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Detalles Bibliográficos
Autores principales: Ishimaru, Yuki, Sumino, Akihide, Shibagaki, Fumiya, Yamamuro, Akiko, Yoshioka, Yasuhiro, Maeda, Sadaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141441/
https://www.ncbi.nlm.nih.gov/pubmed/32296325
http://dx.doi.org/10.3389/fnagi.2020.00058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141441/
https://www.ncbi.nlm.nih.gov/pubmed/32296325
http://dx.doi.org/10.3389/fnagi.2020.00058

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