Cargando…

NMDA receptor channel gating control by the pre-M1 helix

The NMDA receptor (NMDAR) is an ionotropic glutamate receptor formed from the tetrameric assembly of GluN1 and GluN2 subunits. Within the flexible linker between the agonist binding domain (ABD) and the M1 helix of the pore-forming transmembrane helical bundle lies a two-turn, extracellular pre-M1 h...

Descripción completa

Detalles Bibliográficos
Autores principales:	McDaniel, Miranda J., Ogden, Kevin K., Kell, Steven A., Burger, Pieter B., Liotta, Dennis C., Traynelis, Stephen F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141592/ https://www.ncbi.nlm.nih.gov/pubmed/32221541 http://dx.doi.org/10.1085/jgp.201912362

Ejemplares similares

A structurally derived model of subunit‐dependent NMDA receptor function
por: Gibb, Alasdair J., et al.
Publicado: (2018)

The pre-M1 helix controls NMDA receptor gating
por: Short, Ben
Publicado: (2020)

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology
por: Ogden, Kevin K., et al.
Publicado: (2017)

Biased modulators of NMDA receptors control channel opening and ion selectivity
por: Perszyk, Riley E., et al.
Publicado: (2020)

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
por: Regan, Michael C., et al.
Publicado: (2019)

Cadmium activates AMPA and NMDA receptors with M3 helix cysteine substitutions
por: Wilding, Timothy J., et al.
Publicado: (2020)

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate
por: Ladislav, Marek, et al.
Publicado: (2018)

H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels
por: Rapedius, Markus, et al.
Publicado: (2007)

Dynamic role of the tether helix in PIP(2)-dependent gating of a G protein–gated potassium channel
por: Lacin, Emre, et al.
Publicado: (2017)

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups
por: Perszyk, Riley, et al.
Publicado: (2018)

Subunit-specific Contribution of Pore-forming Domains to NMDA Receptor Channel Structure and Gating
por: Sobolevsky, Alexander I., et al.
Publicado: (2007)

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
por: Kasimova, Marina A, et al.
Publicado: (2019)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

The structure-energy landscape of NMDA Receptor gating
por: Dolino, Drew M., et al.
Publicado: (2017)

The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel
por: Meng, Xuan-Yu, et al.
Publicado: (2016)

Role of Cross-Cleft Contacts in NMDA Receptor Gating
por: Paganelli, Meaghan A., et al.
Publicado: (2013)

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
por: Park, Hyungju, et al.
Publicado: (2015)

TRESK background potassium channel is not gated at the helix bundle crossing near the cytoplasmic end of the pore
por: Lengyel, Miklós, et al.
Publicado: (2018)

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
por: Zheng, Wang, et al.
Publicado: (2019)

Interactions between selectivity filter and pore helix control filter gating in the MthK channel
por: Kopec, Wojciech, et al.
Publicado: (2023)

Modulation of NMDA channel gating by Ca(2+) and Cd(2+) binding to the external pore mouth
por: Tu, Ya-Chi, et al.
Publicado: (2016)

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney
por: Valdivielso, José M., et al.
Publicado: (2020)

Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
por: Park, Hyungju, et al.
Publicado: (2021)

Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model
por: Harris, Lynnea D., et al.
Publicado: (2023)

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
por: Yamashita, Megumi, et al.
Publicado: (2017)

Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5
por: Kwag, Jeehyun, et al.
Publicado: (2012)

Extracellular Ca(2+) ions reduce NMDA receptor conductance and gating
por: Maki, Bruce A., et al.
Publicado: (2014)

Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel
por: Ramis, Rafael, et al.
Publicado: (2022)

Distinct functional roles for the M4 α-helix from each homologous subunit in the heteropentameric ligand-gated ion channel nAChR
por: Thompson, Mackenzie J., et al.
Publicado: (2022)

N-Methyl-D-Aspartate(NMDA) Receptor and Voltage-Gated Potassium Channel (VGKC) Antibody-Associated Encephalitides Presenting as First Episode Acute Psychosis
por: Tang, Charmaine, et al.
Publicado: (2019)

Importance of the αC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis
por: Chin, Kimberley, et al.
Publicado: (2010)

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine
por: Choudhury, Koushik, et al.
Publicado: (2022)

Cross-subunit interactions that stabilize open states mediate gating in NMDA receptors
por: Iacobucci, Gary J., et al.
Publicado: (2021)

Two gates mediate NMDA receptor activity and are under subunit-specific regulation
por: Amin, Johansen B., et al.
Publicado: (2023)

Mechanism of CaMKII regulation of AMPA receptor gating
por: Kristensen, Anders S., et al.
Publicado: (2011)

Ion channels in EEG: isolating channel dysfunction in NMDA receptor antibody encephalitis
por: Symmonds, Mkael, et al.
Publicado: (2018)

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca(2+) channels upstream of p38 MAPK
por: Sanchez, Ana B., et al.
Publicado: (2016)

Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines
por: Stein, Ivar S., et al.
Publicado: (2021)

Inhibition of NMDA receptors through a membrane-to-channel path
por: Wilcox, Madeleine R., et al.
Publicado: (2022)

Aromatic–aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process
por: Garneau, Line, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_us2sii8bh7g2qtj7shtgsd7pf8