Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge

Human KCNH2 channels (hKCNH2, ether-à-go-go [EAG]–related gene, hERG) are best known for their contribution to cardiac action potential repolarization and have key roles in various pathologies. Like other KCNH family members, hKCNH2 channels contain a unique intracellular complex, consisting of an N...

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Detalles Bibliográficos
Autores principales: Ben-Bassat, Ariel, Giladi, Moshe, Haitin, Yoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141593/
https://www.ncbi.nlm.nih.gov/pubmed/32191791
http://dx.doi.org/10.1085/jgp.201912505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141593/
https://www.ncbi.nlm.nih.gov/pubmed/32191791
http://dx.doi.org/10.1085/jgp.201912505

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