Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression

The telomerase reverse transcriptase (TERT) gene is responsible for telomere maintenance in germline and stem cells, and is re-expressed in 90% of human cancers. CpG methylation in the TERT promoter (TERTp) was correlated with TERT mRNA expression. Furthermore, two hotspot mutations in TERTp, dubbed...

Descripción completa

Detalles Bibliográficos
Autores principales: Salgado, Catarina, Roelse, Celine, Nell, Rogier, Gruis, Nelleke, van Doorn, Remco, van der Velden, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141627/
https://www.ncbi.nlm.nih.gov/pubmed/32267900
http://dx.doi.org/10.1371/journal.pone.0231418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141627/
https://www.ncbi.nlm.nih.gov/pubmed/32267900
http://dx.doi.org/10.1371/journal.pone.0231418

Ejemplares similares