Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

The many variants of human Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) differ in the lengths and sequences of disordered linkers connecting the kinase domains to the oligomeric hubs of the holoenzyme. CaMKII activity depends on the balance between activating and inhibitory autophosphoryla...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Moitrayee, Lee, Young Kwang, Muratcioglu, Serena, Qiu, Baiyu, Nyayapati, Priya, Schulman, Howard, Groves, Jay T, Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141811/
https://www.ncbi.nlm.nih.gov/pubmed/32149607
http://dx.doi.org/10.7554/eLife.53670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141811/
https://www.ncbi.nlm.nih.gov/pubmed/32149607
http://dx.doi.org/10.7554/eLife.53670

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