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Cooperativity of K(v)7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells
The mammalian cochlea relies on active electromotility of outer hair cells (OHCs) to resolve sound frequencies. OHCs use ionic channels and somatic electromotility to achieve the process. It is unclear, though, how the kinetics of voltage-gated ionic channels operate to overcome extrinsic viscous dr...
Autores principales: | Perez-Flores, Maria C., Lee, Jeong H., Park, Seojin, Zhang, Xiao-Dong, Sihn, Choong-Ryoul, Ledford, Hannah A., Wang, Wenying, Kim, Hyo Jeong, Timofeyev, Valeriy, Yarov-Yarovoy, Vladimir, Chiamvimonvat, Nipavan, Rabbitt, Richard D., Yamoah, Ebenezer N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141818/ https://www.ncbi.nlm.nih.gov/pubmed/32285007 http://dx.doi.org/10.1126/sciadv.aba1104 |
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