The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks

DNA damage tolerance (DDT) is crucial for genome integrity maintenance. DDT is mainly carried out by template switch recombination, an error-free mode of overcoming DNA lesions, or translesion DNA synthesis, which is error-prone. Here, we investigated the role of Mgs1/WRNIP1 in modulating DDT. Using...

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Detalles Bibliográficos
Autores principales: Jiménez-Martín, Alberto, Saugar, Irene, Joseph, Chinnu Rose, Mayer, Alexandra, Lehmann, Carl P., Szakal, Barnabas, Branzei, Dana, Tercero, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141828/
https://www.ncbi.nlm.nih.gov/pubmed/32285001
http://dx.doi.org/10.1126/sciadv.aaz3327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141828/
https://www.ncbi.nlm.nih.gov/pubmed/32285001
http://dx.doi.org/10.1126/sciadv.aaz3327

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