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Force production of human cytoplasmic dynein is limited by its processivity

Cytoplasmic dynein is a highly complex motor protein that generates forces toward the minus end of microtubules. Using optical tweezers, we demonstrate that the low processivity (ability to take multiple steps before dissociating) of human dynein limits its force generation due to premature microtub...

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Detalles Bibliográficos
Autores principales: Brenner, Sibylle, Berger, Florian, Rao, Lu, Nicholas, Matthew P., Gennerich, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141836/
https://www.ncbi.nlm.nih.gov/pubmed/32285003
http://dx.doi.org/10.1126/sciadv.aaz4295