Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-ind...

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Detalles Bibliográficos
Autores principales: Béchet, Sibylle, O'Sullivan, Sinead A., Yssel, Justin, Fagan, Steven G., Dev, Kumlesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141882/
https://www.ncbi.nlm.nih.gov/pubmed/32127495
http://dx.doi.org/10.1523/JNEUROSCI.2346-19.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141882/
https://www.ncbi.nlm.nih.gov/pubmed/32127495
http://dx.doi.org/10.1523/JNEUROSCI.2346-19.2020

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