Cargando…

Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Béchet, Sibylle, O'Sullivan, Sinead A., Yssel, Justin, Fagan, Steven G., Dev, Kumlesh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141882/ https://www.ncbi.nlm.nih.gov/pubmed/32127495 http://dx.doi.org/10.1523/JNEUROSCI.2346-19.2020

Ejemplares similares

Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer’s Disease
por: Fagan, Steven G., et al.
Publicado: (2022)

The Effects of Antipsychotics in Experimental Models of Krabbe Disease
por: Sharma, Kapil, et al.
Publicado: (2023)

Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures
por: Pritchard, Adam J., et al.
Publicado: (2014)

The chemokine fractalkine (CX3CL1) attenuates H(2)O(2)-induced demyelination in cerebellar slices
por: O’Sullivan, Sinead A., et al.
Publicado: (2017)

Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination
por: Misslin, Cedric, et al.
Publicado: (2017)

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
por: O’Sullivan, Catherine, et al.
Publicado: (2016)

Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe’s disease
por: D’Auria, Ludovic, et al.
Publicado: (2017)

Olaparib Attenuates Demyelination and Neuroinflammation in an Organotypic Slice Culture Model of Metachromatic Leukodystrophy
por: Mekhaeil, Marianna, et al.
Publicado: (2023)

Existing Evidence for the Repurposing of PARP-1 Inhibitors in Rare Demyelinating Diseases
por: Mekhaeil, Marianna, et al.
Publicado: (2022)

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
por: O’Sullivan, Sinead A., et al.
Publicado: (2016)

Chronic lithium administration in a mouse model for Krabbe disease
por: Del Grosso, Ambra, et al.
Publicado: (2021)

Visual System Impairment in a Mouse Model of Krabbe Disease: The Twitcher Mouse
por: Tonazzini, Ilaria, et al.
Publicado: (2020)

EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination
por: Rutkowska, Aleksandra, et al.
Publicado: (2017)

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
por: Cappello, Valentina, et al.
Publicado: (2016)

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease
por: Braz, Sandra O., et al.
Publicado: (2023)

Neuroimmune mechanisms in Krabbe's disease
por: Potter, Gregory B., et al.
Publicado: (2016)

The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages
por: Rutkowska, Aleksandra, et al.
Publicado: (2016)

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination
por: Blanc, Caroline A, et al.
Publicado: (2014)

Hybrid Nanoparticles as a Novel Tool for Regulating Psychosine-Induced Neuroinflammation and Demyelination In Vitro and Ex vivo
por: Clementino, Adryana, et al.
Publicado: (2021)

Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease
por: Mezzena, Roberta, et al.
Publicado: (2023)

Tumefactive demyelination with a transient appearance of oligoclonal bands in MS under fingolimod
por: Okada, Kazumasa, et al.
Publicado: (2018)

Advances in the Diagnosis and Treatment of Krabbe Disease
por: Wenger, David A, et al.
Publicado: (2021)

Characterization of adipose-derived stromal/stem cells from the twitcher mouse model of krabbe disease
por: Zhang, Xiujuan, et al.
Publicado: (2013)

The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease
por: Reiter, Cory R., et al.
Publicado: (2022)

Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
por: Brites, Pedro, et al.
Publicado: (2022)

Serendipitous effects of β-cyclodextrin on murine model of Krabbe disease
por: Katabuchi, Asaka U., et al.
Publicado: (2018)

Gene therapy for CNS diseases – Krabbe disease
por: Rafi, Mohammad A.
Publicado: (2016)

Krabbe disease: New hope for an old disease
por: Bradbury, Allison M., et al.
Publicado: (2021)

Azasugar inhibitors as pharmacological chaperones for Krabbe disease
por: Hill, Chris H., et al.
Publicado: (2015)

Krabbe disease: A personal perspective and hypothesis
por: Rafi, Mohammad A.
Publicado: (2022)

Neurodegenerative Disorder Risk in Krabbe Disease Carriers
por: Vantaggiato, Lorenza, et al.
Publicado: (2022)

Globoid Cell Leukodystrophy (Krabbe Disease): An Update
por: Maghazachi, Azzam A
Publicado: (2023)

Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model
por: Lai, Pei-Lun, et al.
Publicado: (2022)

Quantification of 3D Brain Microangioarchitectures in an Animal Model of Krabbe Disease
por: Righi, Marco, et al.
Publicado: (2019)

Reduction in miR‐219 expression underlies cellular pathogenesis of oligodendrocytes in a mouse model of Krabbe disease
por: Inamura, Naoko, et al.
Publicado: (2021)

Neuroprotective Effects of Fingolimod in a Cellular Model of Optic Neuritis
por: Candadai, Amritha A., et al.
Publicado: (2021)

Fingolimod for Irradiation-Induced Neurodegeneration
por: Metzdorf, Judith, et al.
Publicado: (2019)

Optic nerve enlargement in infantile form of Krabbe disease
por: Castilha-Neto, Dimas, et al.
Publicado: (2012)

Adult Krabbe Disease That Was Successfully Treated with Intravenous Immunoglobulin
por: Fukazawa, Ryosuke, et al.
Publicado: (2020)

National U.S. Patient and Transplant Data for Krabbe Disease
por: Ghabash, Gabrielle, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9ecnl3d7qak40hjptl3qjr3otq