The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically

The homeotic protein SIX3 is a transcription factor vital for neurogenesis and has a bivalent promoter. We previously showed that SIX3 can be transcriptionally silenced by DNA hypermethylation, functions as a tumor suppressor gene, and inhibits human glioblastoma transcriptionally. Here, we show tha...

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Detalles Bibliográficos
Autores principales: Yu, Zhibin, Feng, Jianbo, Wang, Wei, Deng, Zhiyong, Zhang, Yan, Xiao, Lan, Wang, Zeyou, Liu, Changhong, Liu, Qing, Chen, Shuai, Wu, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142014/
https://www.ncbi.nlm.nih.gov/pubmed/32051553
http://dx.doi.org/10.1038/s41388-020-1206-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142014/
https://www.ncbi.nlm.nih.gov/pubmed/32051553
http://dx.doi.org/10.1038/s41388-020-1206-7

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