Cargando…

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically

The homeotic protein SIX3 is a transcription factor vital for neurogenesis and has a bivalent promoter. We previously showed that SIX3 can be transcriptionally silenced by DNA hypermethylation, functions as a tumor suppressor gene, and inhibits human glioblastoma transcriptionally. Here, we show tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Zhibin, Feng, Jianbo, Wang, Wei, Deng, Zhiyong, Zhang, Yan, Xiao, Lan, Wang, Zeyou, Liu, Changhong, Liu, Qing, Chen, Shuai, Wu, Minghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142014/ https://www.ncbi.nlm.nih.gov/pubmed/32051553 http://dx.doi.org/10.1038/s41388-020-1206-7

Ejemplares similares

SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
por: Yu, Zhibin, et al.
Publicado: (2017)

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors
por: Wang, Zeyou, et al.
Publicado: (2014)

Bufei Yishen Formula Inhibits the Cell Senescence in COPD by Up-Regulating the ZNF263 and Klotho Expression
por: Wang, Weimin, et al.
Publicado: (2023)

Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma
por: Jiang, Dong, et al.
Publicado: (2018)

COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding
por: Nemani, Sai Sneha Priya, et al.
Publicado: (2021)

A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
por: Cui, Jie, et al.
Publicado: (2020)

Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas
por: Li, Jie, et al.
Publicado: (2014)

Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-β-catenin axis
por: Han, Bo, et al.
Publicado: (2017)

Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction
por: Liu, Chang, et al.
Publicado: (2017)

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons
por: Ma, Longfei, et al.
Publicado: (2021)

Function and Transcriptional Regulation of Bovine TORC2 Gene in Adipocytes: Roles of C/EBPγ, XBP1, INSM1 and ZNF263
por: Khan, Rajwali, et al.
Publicado: (2019)

ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage
por: Liu, Jun, et al.
Publicado: (2022)

Coagulation Factor X Regulated by CASC2c Recruited Macrophages and Induced M2 Polarization in Glioblastoma Multiforme
por: Zhang, Yan, et al.
Publicado: (2018)

BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation
por: Zhan, Yihong, et al.
Publicado: (2019)

ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis
por: Gong, Wei, et al.
Publicado: (2021)

Corrigendum: Coagulation Factor X Regulated by CASC2c Recruited Macrophages and Induced M2 Polarization in Glioblastoma Multiforme
por: Zhang, Yan, et al.
Publicado: (2020)

Silenced ZNF154 Is Associated with Longer Survival in Resectable Pancreatic Cancer
por: Wiesmueller, Felix, et al.
Publicado: (2019)

Health Tract, No. 263: Experimenting
Publicado: (1867)

Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide
por: Feng, Jianbo, et al.
Publicado: (2020)

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells
por: Wang, Zeyou, et al.
Publicado: (2016)

High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases
por: Nätt, Daniel, et al.
Publicado: (2015)

ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
por: Li, Lifang, et al.
Publicado: (2017)

miR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma
por: Sun, Yingnan, et al.
Publicado: (2014)

Correction to: miR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma
por: Sun, Yingnan, et al.
Publicado: (2021)

ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer
por: Gloss, Brian, et al.
Publicado: (2014)

A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of Autosomal Dwarfism in Chicken
por: Wu, Zhou, et al.
Publicado: (2018)

Efficacy of erlotinib in NSCLC harboring rare EGFR extracellular domain mutation (T263P) and common mutations: Case report and literature review
por: Wang, Qian, et al.
Publicado: (2022)

MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells
por: Liu, Xiaoping, et al.
Publicado: (2015)

Correction: MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells
por: Liu, Xiaoping, et al.
Publicado: (2020)

Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines
por: Ayala-Ortega, Erandi, et al.
Publicado: (2016)

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition
por: Sarver, Dylan C., et al.
Publicado: (2023)

A NIK-SIX signaling axis controls inflammation by targeted silencing of noncanonical NF-κB
por: Liu, Zixu, et al.
Publicado: (2019)

Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances
por: Chen, Zhi, et al.
Publicado: (2021)

Expression of dedifferentiation markers and multilineage markers in U251 glioblastoma cells with silenced EGFR and FGFR genes
por: XIE, JUE, et al.
Publicado: (2014)

New Insights into Regulatory T Cells: Exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells
por: Li, Peiyao, et al.
Publicado: (2016)

Epigenetic Silencing of miR-9 Promotes Migration and Invasion by EZH2 in Glioblastoma Cells
por: Chien, Yi-Chung, et al.
Publicado: (2020)

ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15
por: Wang, Shuang, et al.
Publicado: (2020)

Expression pattern of ZNF33B in bovine ovaries and the effect of its polymorphism on superovulation traits
por: Li, Changhong, et al.
Publicado: (2022)

Contents of volumes 263, 264, 266–289
Publicado: (1998)

A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy
por: Liu, Changhong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8kpnl77fbq0pkp7l1cf3ssaehn