Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity

The neuropathological hallmarks of Parkinson’s disease include preferential vulnerability of dopaminergic neurons of the substantia nigra pars compacta, and accumulation of intraneuronal protein inclusions known as Lewy bodies. These inclusions contain, among other proteins, aggregated alpha-synucle...

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Detalles Bibliográficos
Autores principales: Francelle, Laetitia, Outeiro, Tiago F., Rappold, Gudrun A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142125/
https://www.ncbi.nlm.nih.gov/pubmed/32269243
http://dx.doi.org/10.1038/s41598-020-62678-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142125/
https://www.ncbi.nlm.nih.gov/pubmed/32269243
http://dx.doi.org/10.1038/s41598-020-62678-5

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