GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells

GJB2 gene (that encodes Cx26) mutations are causal of hearing loss highlighting the importance of Cx26-based channel signaling amongst the supporting cells in the organ of Corti. While the majority of these GJB2 mutations are inherited in an autosomal recessive manner, others are inherited in an aut...

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Detalles Bibliográficos
Autores principales: Beach, Rianne, Abitbol, Julia M., Allman, Brian L., Esseltine, Jessica L., Shao, Qing, Laird, Dale W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142214/
https://www.ncbi.nlm.nih.gov/pubmed/32300592
http://dx.doi.org/10.3389/fcell.2020.00215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142214/
https://www.ncbi.nlm.nih.gov/pubmed/32300592
http://dx.doi.org/10.3389/fcell.2020.00215

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