Cargando…

Influence of Dominance and Drift on Lethal Mutations in Human Populations

We consider disease-causing mutations that are lethal when homozygous. Lethality involves the very strongest form of negative selection, with the selection coefficient against the disease-carrying homozygote having its maximum value of unity. We determine results for the behavior of the frequency of...

Descripción completa

Detalles Bibliográficos
Autores principales: Waxman, David, Overall, Andrew D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142268/
https://www.ncbi.nlm.nih.gov/pubmed/32300356
http://dx.doi.org/10.3389/fgene.2020.00267