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Influence of Dominance and Drift on Lethal Mutations in Human Populations
We consider disease-causing mutations that are lethal when homozygous. Lethality involves the very strongest form of negative selection, with the selection coefficient against the disease-carrying homozygote having its maximum value of unity. We determine results for the behavior of the frequency of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142268/ https://www.ncbi.nlm.nih.gov/pubmed/32300356 http://dx.doi.org/10.3389/fgene.2020.00267 |