Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents

Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4′-chloromethyl-2′-deoxy-2′-fluoro nucleoside ALS-8112, was evaluated in hospitalized infants for the treatment of...

Descripción completa

Detalles Bibliográficos
Autores principales: Kasthuri, Mahesh, Li, Chengwei, Verma, Kiran, Russell, Olivia Ollinger, Dickson, Lyndsey, McCormick, Louise, Bassit, Leda, Amblard, Franck, Schinazi, Raymond F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143966/
https://www.ncbi.nlm.nih.gov/pubmed/32168734
http://dx.doi.org/10.3390/molecules25061258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143966/
https://www.ncbi.nlm.nih.gov/pubmed/32168734
http://dx.doi.org/10.3390/molecules25061258

Ejemplares similares