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Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities
Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis. However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity. We used site-directed mutagenesis to identify the residues criti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144311/ https://www.ncbi.nlm.nih.gov/pubmed/32180482 http://dx.doi.org/10.1080/14756366.2020.1740691 |