Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities

Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis. However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity. We used site-directed mutagenesis to identify the residues criti...

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Detalles Bibliográficos
Autores principales: Noh, Hyangsoon, Lee, Sung Jun, Jo, Hyun-Joo, Choi, Hye Won, Hong, Sungguan, Kong, Kwang-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144311/
https://www.ncbi.nlm.nih.gov/pubmed/32180482
http://dx.doi.org/10.1080/14756366.2020.1740691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144311/
https://www.ncbi.nlm.nih.gov/pubmed/32180482
http://dx.doi.org/10.1080/14756366.2020.1740691

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