S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

We evaluated the hCA (CA, EC 4.2.1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides (compounds 2–20) towards the isoforms I, II, IX, and XII. hCA Isoforms were effectively inhibited by most of new compounds comparable to those of AAZ. Compou...

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Detalles Bibliográficos
Autores principales: El-Azab, Adel S., Abdel-Aziz, Alaa A.-M., Bua, Silvia, Nocentini, Alessio, AlSaif, Nawaf A., Alanazi, Mohammed M., El-Gendy, Manal A., Ahmed, Hany E. A., Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144323/
https://www.ncbi.nlm.nih.gov/pubmed/32189526
http://dx.doi.org/10.1080/14756366.2020.1742117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144323/
https://www.ncbi.nlm.nih.gov/pubmed/32189526
http://dx.doi.org/10.1080/14756366.2020.1742117

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