Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening

ATAD2 has been reported to play an important role in the processes of numerous cancers and validated to be a potential therapeutic target. This work is to discover potent ATAD2 inhibitors and elucidate the underlying mechanisms in breast cancer. A novel ATAD2 bromodomain inhibitor (AM879) was discov...

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Detalles Bibliográficos
Autores principales: Yao, Dahong, Zhang, Jin, Wang, Jinhui, Pan, Dabo, He, Zhendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144325/
https://www.ncbi.nlm.nih.gov/pubmed/32174193
http://dx.doi.org/10.1080/14756366.2020.1740924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144325/
https://www.ncbi.nlm.nih.gov/pubmed/32174193
http://dx.doi.org/10.1080/14756366.2020.1740924

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