Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability

Fostemsavir/temsavir is an investigational HIV-1 entry inhibitor currently in late-stage clinical trials. Although it holds promise to be a first-in-class Env-targeted entry inhibitor for the clinic, issues with bioavailability relegate its use to salvage therapies only. As such, the development of...

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Detalles Bibliográficos
Autores principales: Karadsheh, Rama, Meuser, Megan E., Cocklin, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144373/
https://www.ncbi.nlm.nih.gov/pubmed/32245167
http://dx.doi.org/10.3390/molecules25061430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144373/
https://www.ncbi.nlm.nih.gov/pubmed/32245167
http://dx.doi.org/10.3390/molecules25061430

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