Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases

In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated 5-IP7 promotes insulin secretion from pancrea...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sandip, Haubner, Jake, Chakraborty, Anutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144392/
https://www.ncbi.nlm.nih.gov/pubmed/32204420
http://dx.doi.org/10.3390/molecules25061403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144392/
https://www.ncbi.nlm.nih.gov/pubmed/32204420
http://dx.doi.org/10.3390/molecules25061403

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