Cargando…

Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases

In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated 5-IP7 promotes insulin secretion from pancrea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mukherjee, Sandip, Haubner, Jake, Chakraborty, Anutosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144392/ https://www.ncbi.nlm.nih.gov/pubmed/32204420 http://dx.doi.org/10.3390/molecules25061403

Ejemplares similares

Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction
por: Ghoshal, Sarbani, et al.
Publicado: (2022)

The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling
por: Mukherjee, Sandip, et al.
Publicado: (2023)

Preparation of Quality Inositol Pyrophosphates
por: Loss, Omar, et al.
Publicado: (2011)

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
por: Hostachy, Sarah, et al.
Publicado: (2021)

Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues
por: Shears, Stephen B., et al.
Publicado: (2020)

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals
por: Lee, Seulgi, et al.
Publicado: (2020)

Inositol Pyrophosphates and Their Unique Metabolic Complexity: Analysis by Gel Electrophoresis
por: Losito, Oriana, et al.
Publicado: (2009)

Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis
por: Pisani, Francesca, et al.
Publicado: (2014)

Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
por: Shah, Akruti, et al.
Publicado: (2017)

Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses
por: Park, Seung Ju, et al.
Publicado: (2020)

A Role for Inositol Pyrophosphates in the Metabolic Adaptations to Low Phosphate in Arabidopsis
por: Land, Eric S., et al.
Publicado: (2021)

Biosynthesis and possible functions of inositol pyrophosphates in plants
por: Williams, Sarah P., et al.
Publicado: (2015)

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles
por: Frej, Anna D., et al.
Publicado: (2016)

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?
por: Freed, Catherine, et al.
Publicado: (2020)

Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes
por: Furkert, David, et al.
Publicado: (2021)

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs
por: Hostachy, Sarah, et al.
Publicado: (2023)

Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair
por: Jadav, Rathan S., et al.
Publicado: (2013)

Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers
por: Gaugler, Philipp, et al.
Publicado: (2022)

Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?
por: Cridland, Caitlin, et al.
Publicado: (2020)

Fungal Inositol Pyrophosphate IP(7) Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity
por: Lev, Sophie, et al.
Publicado: (2015)

Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity
por: Kang, Hyun Ah
Publicado: (2018)

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe
por: Kuenzel, Natascha Andrea, et al.
Publicado: (2022)

Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis
por: Mukherjee, Sandip, et al.
Publicado: (2021)

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis
por: Desfougères, Yann, et al.
Publicado: (2022)

Inhibitors of Testosterone Biosynthetic and Metabolic Activation Enzymes
por: Ye, Leping, et al.
Publicado: (2011)

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
por: Zhu, Jinsheng, et al.
Publicado: (2019)

Role of Inositols and Inositol Phosphates in Energy Metabolism
por: Chatree, Saimai, et al.
Publicado: (2020)

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
por: Baughman, Brandi M., et al.
Publicado: (2016)

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
por: Qiu, Danye, et al.
Publicado: (2022)

Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo
por: Mukherjee, Sandip, et al.
Publicado: (2023)

Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic Genes
por: King, Jason, et al.
Publicado: (2010)

Aging as an essential modifier for the efficacy in mesenchymal stem cell therapy through an inositol phosphate 6 kinase-inositol pyrophosphate 7-dependent mechanism
por: Wang, Sherry Shuyi, et al.
Publicado: (2014)

Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae
por: Thota, Swarna Gowri, et al.
Publicado: (2015)

Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
por: Nair, Vasudha S., et al.
Publicado: (2018)

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
por: Baughman, Brandi M., et al.
Publicado: (2017)

Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination
por: Sanchez, Ana M, et al.
Publicado: (2019)

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase
por: Mohanrao, Raja, et al.
Publicado: (2021)

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP(7)
por: Sahu, Soumyadip, et al.
Publicado: (2023)

Pyrophosphate metabolism and calcification
por: Hamczyk, Magda R., et al.
Publicado: (2018)

Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling
por: Zhang, Zheng, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lvhr29a1cp0g0rn2gfikb7p39o