Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Progressive loss of retinal ganglion cells (RGCs) leads to irreversible visual deficits in glaucoma. Here, we found that the level of cyclic AMP and the activity and expression of its mediator Epac1 were increased in retinas of two mouse models of ocular hypertension. Genetic depletion of Epac1 sign...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Ha, Yonju, Xia, Fan, Zhu, Shuang, Li, Yi, Shi, Shuizhen, Mei, Fang C., Merkley, Kevin, Vizzeri, Gianmarco, Motamedi, Massoud, Cheng, Xiaodong, Liu, Hua, Zhang, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144517/
https://www.ncbi.nlm.nih.gov/pubmed/31918438
http://dx.doi.org/10.1084/jem.20190930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144517/
https://www.ncbi.nlm.nih.gov/pubmed/31918438
http://dx.doi.org/10.1084/jem.20190930

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