Cargando…

2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication

The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase (RT)-associated ribonuclease H (RNase H) function is a promising drug target. Here we report a series of compounds, devel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corona, Angela, Onnis, Valentina, Del Vecchio, Claudia, Esposito, Francesca, Cheng, Yung-Chi, Tramontano, Enzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144554/ https://www.ncbi.nlm.nih.gov/pubmed/32183488 http://dx.doi.org/10.3390/molecules25061338

Ejemplares similares

Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor
por: Corona, Angela, et al.
Publicado: (2013)

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions
por: Meleddu, Rita, et al.
Publicado: (2021)

An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst
por: Yarhosseini, Mahsa, et al.
Publicado: (2017)

HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions
por: Esposito, Francesca, et al.
Publicado: (2012)

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain
por: Carcelli, Mauro, et al.
Publicado: (2017)

Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication
por: Sanna, Cinzia, et al.
Publicado: (2018)

Synthetic and oxidative studies on 8-(arylamino)-2'-deoxyguanosine and -guanosine derivatives.
por: Johnson, F, et al.
Publicado: (1994)

Synthesis and In Vitro Cytotoxic Properties of Polycarbo-Substituted 4-(Arylamino)quinazolines
por: Paumo, Hugues Kamdem, et al.
Publicado: (2016)

5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
por: Corona, Angela, et al.
Publicado: (2023)

Development and Validation of a Novel Dual Luciferase Reporter Gene Assay to Quantify Ebola Virus VP24 Inhibition of IFN Signaling
por: Fanunza, Elisa, et al.
Publicado: (2018)

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
por: Meleddu, Rita, et al.
Publicado: (2016)

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase
por: Matheson, Christopher J., et al.
Publicado: (2020)

Synthesis, Reactivity and Antimicrobial Activity of a Series of 2-Arylamino-1,3-selenazoles
por: Kuchar, Julia, et al.
Publicado: (2021)

Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent
por: Uchikura, Tatsuhiro, et al.
Publicado: (2020)

Quaternary Ammonium Salt Strategy and Molecular Docking Studies of Novel 5-Acyl-8-(Arylamino)-Quinolines by Acetyl and Methanesulfonyl Chloride for Dual Evaluation Bioactivity
por: Feng Jin, et al.
Publicado: (2023)

Chemoselective cyclization of 3-arylamino-2-hydroxy-tetrahydroindol-4-one in water at room temperature
por: Rahimi, Fatemeh, et al.
Publicado: (2019)

Ultrasound-assisted Strecker synthesis of novel 2-(hetero)aryl-2-(arylamino)acetonitrile derivatives
por: Gal, Emese, et al.
Publicado: (2020)

Antiviral Agents Against Ebola Virus Infection: Repositioning Old Drugs and Finding Novel Small Molecules
por: Fanunza, Elisa, et al.
Publicado: (2018)

Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration
por: Quiliano, Miguel, et al.
Publicado: (2016)

Antimycobacterial and Photosynthetic Electron Transport Inhibiting Activity of Ring-Substituted 4-Arylamino-7-Chloroquinolinium Chlorides
por: Otevrel, Jan, et al.
Publicado: (2013)

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6
por: Corona, Angela, et al.
Publicado: (2016)

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants
por: Corona, Angela, et al.
Publicado: (2020)

Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent
por: Wang, Xiao-Ping, et al.
Publicado: (2013)

Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence
por: Zuo, Lingjun, et al.
Publicado: (2016)

A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
por: Ouyang, Guiping, et al.
Publicado: (2005)

Novel 1-[5-(4-bromophenoxy)pentyl]-3-(2-arylamino- 2-oxoethyl)uracils and their antiviral properties
por: Paramonova, Maria P., et al.
Publicado: (2017)

2,7(3,6)-Diaryl(arylamino)-substituted Carbazoles as Components of OLEDs: A Review of the Last Decade
por: Krucaite, Gintare, et al.
Publicado: (2021)

Recovery of Gallium-68 and Zinc from HNO(3)-Based Solution by Liquid–Liquid Extraction with Arylamino Phosphonates
por: Zhuravlev, Fedor, et al.
Publicado: (2022)

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds
por: Sanna, Cinzia, et al.
Publicado: (2021)

Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly
por: Sun, Xiaoyu, et al.
Publicado: (2018)

Trifluoromethyl-substituted tetrathiafulvalenes
por: Jeannin, Olivier, et al.
Publicado: (2015)

HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France)
por: Sanna, Cinzia, et al.
Publicado: (2023)

Natural and Nature-Derived Products Targeting Human Coronaviruses
por: Vougogiannopoulou, Konstantina, et al.
Publicado: (2021)

Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolones with Trifluoromethyl Ketones
por: Carceller-Ferrer, Laura, et al.
Publicado: (2022)

Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication
por: Asthana, Abhishek, et al.
Publicado: (2023)

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime
por: Gonçalves, Raoni S B, et al.
Publicado: (2013)

Product Control in Alkene Trifluoromethylation: Hydrotrifluoromethylation, Vinylic Trifluoromethylation, and Iodotrifluoromethylation using Togni Reagent
por: Egami, Hiromichi, et al.
Publicado: (2015)

Investigating Spectrum of Biological Activity of 4- and 5-Chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides
por: Imramovsky, Ales, et al.
Publicado: (2011)

Impact of human immunodeficiency virus type 1 ribonuclease H inhibitors on the polymerase and RNase H function of foamy virus reverse transcriptase
por: Corona, Angela, et al.
Publicado: (2013)

Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata
por: Guzzo, Francesca, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ipo865acr0jvdrhed4rif0bldi