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The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates
DNA ligase I and DNA ligase III/XRCC1 complex catalyze the ultimate ligation step following DNA polymerase (pol) β nucleotide insertion during base excision repair (BER). Pol β Asn279 and Arg283 are the critical active site residues for the differentiation of an incoming nucleotide and a template ba...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144901/ https://www.ncbi.nlm.nih.gov/pubmed/32140717 http://dx.doi.org/10.1093/nar/gkaa151 |