Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo

MeCP2 is a nuclear protein that binds to sites of cytosine methylation in the genome. While most evidence confirms this epigenetic mark as the primary determinant of DNA binding, MeCP2 is also reported to have an affinity for non-methylated DNA sequences. Here we investigated the molecular basis and...

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Detalles Bibliográficos
Autores principales: Connelly, John C, Cholewa-Waclaw, Justyna, Webb, Shaun, Steccanella, Verdiana, Waclaw, Bartlomiej, Bird, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144902/
https://www.ncbi.nlm.nih.gov/pubmed/32064528
http://dx.doi.org/10.1093/nar/gkaa102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144902/
https://www.ncbi.nlm.nih.gov/pubmed/32064528
http://dx.doi.org/10.1093/nar/gkaa102

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