Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation

Genomic instability resulting from defective DNA damage responses or repair causes several abnormalities, including progressive cerebellar ataxia, for which the molecular mechanisms are not well understood. Here, we report a new murine model of cerebellar ataxia resulting from concomitant inactivati...

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Detalles Bibliográficos
Autores principales: Kim, Jusik, Kim, Keeeun, Mo, Jung-soon, Lee, Youngsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144915/
https://www.ncbi.nlm.nih.gov/pubmed/32123907
http://dx.doi.org/10.1093/nar/gkaa140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144915/
https://www.ncbi.nlm.nih.gov/pubmed/32123907
http://dx.doi.org/10.1093/nar/gkaa140

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