Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre

Developing B cells undergo V(D)J recombination to generate a vast repertoire of Ig molecules. V(D)J recombination is initiated by the RAG1/RAG2 complex in recombination centres (RCs), where gene segments become accessible to the complex. Whether transcription is the causal factor of accessibility or...

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Detalles Bibliográficos
Autores principales: Oudinet, Chloé, Braikia, Fatima-Zohra, Dauba, Audrey, Khamlichi, Ahmed Amine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144927/
https://www.ncbi.nlm.nih.gov/pubmed/32086526
http://dx.doi.org/10.1093/nar/gkaa108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144927/
https://www.ncbi.nlm.nih.gov/pubmed/32086526
http://dx.doi.org/10.1093/nar/gkaa108

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