Cargando…

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre

Developing B cells undergo V(D)J recombination to generate a vast repertoire of Ig molecules. V(D)J recombination is initiated by the RAG1/RAG2 complex in recombination centres (RCs), where gene segments become accessible to the complex. Whether transcription is the causal factor of accessibility or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oudinet, Chloé, Braikia, Fatima-Zohra, Dauba, Audrey, Khamlichi, Ahmed Amine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144927/ https://www.ncbi.nlm.nih.gov/pubmed/32086526 http://dx.doi.org/10.1093/nar/gkaa108

Ejemplares similares

Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus
por: Oudinet, Chloé, et al.
Publicado: (2019)

Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination
por: Oudinet, Chloé, et al.
Publicado: (2022)

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination
por: Santos, Joana M., et al.
Publicado: (2018)

Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells
por: Holwerda, Sjoerd J. B., et al.
Publicado: (2013)

Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex
por: Willhoft, Oliver, et al.
Publicado: (2016)

H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation
por: Xu, Zhiliang, et al.
Publicado: (2016)

PHB regulates meiotic recombination via JAK2-mediated histone modifications in spermatogenesis
por: Zhang, Ling-Fei, et al.
Publicado: (2020)

Repression of a large number of genes requires interplay between homologous recombination and HIRA
por: Misova, Ivana, et al.
Publicado: (2021)

Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination
por: Sakuno, Takeshi, et al.
Publicado: (2022)

Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast
por: Yamada, Shintaro, et al.
Publicado: (2013)

The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast
por: Yamada, Shintaro, et al.
Publicado: (2018)

Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context
por: Le Noir, Sandrine, et al.
Publicado: (2017)

A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium
por: Torres-Puig, Sergi, et al.
Publicado: (2015)

An ectopic CTCF-dependent transcriptional insulator influences the choice of Vβ gene segments for VDJ recombination at TCRβ locus
por: Shrimali, Sweety, et al.
Publicado: (2012)

DNA knots occur in intracellular chromatin
por: Valdés, Antonio, et al.
Publicado: (2018)

Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci
por: Rother, Magdalena B., et al.
Publicado: (2016)

Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements
por: Dauba, Audrey, et al.
Publicado: (2021)

Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo
por: Connelly, John C, et al.
Publicado: (2020)

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain
por: Stuss, David P., et al.
Publicado: (2013)

Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation
por: Gao, Zeqian, et al.
Publicado: (2023)

Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures
por: Lee, Seung-Tae, et al.
Publicado: (2015)

40S recruitment in the absence of eIF4G/4A by EMCV IRES refines the model for translation initiation on the archetype of Type II IRESs
por: Chamond, Nathalie, et al.
Publicado: (2014)

Heavy transcription of yeast genes correlates with differential loss of histone H2B relative to H4 and queued RNA polymerases
por: Cole, Hope A., et al.
Publicado: (2014)

Casein kinase 2 mediated phosphorylation of Spt6 modulates histone dynamics and regulates spurious transcription
por: Gouot, Emmanuelle, et al.
Publicado: (2018)

A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells
por: Balaratnam, Sumirtha, et al.
Publicado: (2018)

Essential role of the initial activation signal in isotype selection upon deletion of a transcriptionally committed promoter
por: Santos, Joana M., et al.
Publicado: (2019)

Extracellular signal-regulated kinase 1/2-mediated phosphorylation of p300 enhances myosin heavy chain I/β gene expression via acetylation of nuclear factor of activated T cells c1
por: Meissner, Joachim D., et al.
Publicado: (2011)

Long 3′-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae
por: Kebaara, Bessie W., et al.
Publicado: (2009)

Enhancer-mediated enrichment of interacting JMJD3–DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription
por: Argaud, Deborah, et al.
Publicado: (2019)

Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing
por: Lai, Xuelei, et al.
Publicado: (2020)

Chromatin opening ability of pioneer factor Pax7 depends on unique isoform and C-terminal domain
por: Bascunana, Virginie, et al.
Publicado: (2023)

Pax7 pioneer factor action requires both paired and homeo DNA binding domains
por: Pelletier, Audrey, et al.
Publicado: (2021)

Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1
por: Bentrari, Fatima, et al.
Publicado: (2015)

Tetramerization of MADS family transcription factors SEPALLATA3 and AGAMOUS is required for floral meristem determinacy in Arabidopsis
por: Hugouvieux, Véronique, et al.
Publicado: (2018)

Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription
por: Fenard, David, et al.
Publicado: (2009)

SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression
por: Cioetto-Mazzabò, Laura, et al.
Publicado: (2022)

TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers
por: McIntyre, Alexander J, et al.
Publicado: (2022)

The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress
por: Lemaitre, Florence, et al.
Publicado: (2022)

RNA helicase-dependent gene looping impacts messenger RNA processing
por: Terrone, Sophie, et al.
Publicado: (2022)

The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development
por: Lardenois, Aurélie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_arho05j2j2899dm8hl4mli8ach