Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing intracellular enzyme that catalyzes the first and rate-determining step of tryptophan metabolism and is an important immunotherapeutic target for the treatment of cancer. In this study, we designed and synthesized a new series of compounds as...

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Detalles Bibliográficos
Autores principales: Zhou, Chuan, Lai, Fangfang, Sheng, Li, Chen, Xiaoguang, Li, Yan, Feng, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144934/
https://www.ncbi.nlm.nih.gov/pubmed/32210078
http://dx.doi.org/10.3390/molecules25061447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144934/
https://www.ncbi.nlm.nih.gov/pubmed/32210078
http://dx.doi.org/10.3390/molecules25061447

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