Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function

Modified DNA bases functionally distinguish the taxonomic forms of life—5-methylcytosine separates prokaryotes from eukaryotes and 5-hydroxymethylcytosine ((5hm)C) invertebrates from vertebrates. We demonstrate here that mouse endonuclease G (mEndoG) shows specificity for both (5hm)C and Holliday ju...

Descripción completa

Detalles Bibliográficos
Autores principales: Vander Zanden, Crystal M, Czarny, Ryan S, Ho, Ethan N, Robertson, Adam B, Ho, P Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144941/
https://www.ncbi.nlm.nih.gov/pubmed/32095813
http://dx.doi.org/10.1093/nar/gkaa117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144941/
https://www.ncbi.nlm.nih.gov/pubmed/32095813
http://dx.doi.org/10.1093/nar/gkaa117

Ejemplares similares