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A Zipf-plot based normalization method for high-throughput RNA-seq data
Normalization is crucial in RNA-seq data analyses. Due to the existence of excessive zeros and a large number of small measures, it is challenging to find reliable linear rescaling normalization parameters. We propose a Zipf plot based normalization method (ZN) assuming that all gene profiles have s...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144957/ https://www.ncbi.nlm.nih.gov/pubmed/32271772 http://dx.doi.org/10.1371/journal.pone.0230594 |